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KMID : 1007520160250041147
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Food Science and Biotechnology
2016 Volume.25 No. 4 p.1147 ~ p.1153
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Lithium chloride’s inhibition of 3T3-L1 cell differentiation by regulating the Wnt/β-catenin pathway and enhancing villin 2 expression
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Chi Yu Yang
Shen Jing Lin
Zhang Jing
Shan An Shan
Niu Shu Ling
Zhou Chang Hai
Lee Hong-Gu
Jin Yong Cheng
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Abstract
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The aim of this study is to reveal the relation among villin 2, Wnt/β-catenin, and adipogenesis by adding appropriate lithium chloride (LiCl). The study comprises three parts: the selection of LiCl concentration, the effect of LiCl on adipocyte differentiation during and after differentiation induction. By comprehensively analyzing the results of the experiments, we proved that LiCl can inhibit adipocyte differentiation and enhance villin 2 and β-catenin expressions not only during differentiation induction but also after it. Moreover, villin 2 has a significant impact on β-catenin. We suggest that villin 2 may participate in Wnt/β-catenin signaling.
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KEYWORD
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lithium chloride, villin 2, β-catenin, 3T3-L1, adipocyte differentiation
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